Million Dollar Bike Ride

2023 MDBR


The University of Pennsylvania’s Orphan Disease Center (ODC) is hosting their annual Million Dollar Bike Ride (MDBR), and RASopathies Network has the opportunity to raise funds for international RASopathies research!

If you like to bike, or know of people who do, please sign up to support the RASopathies Network Riders!

  • In-Person Cyclist Registration:
    • $35 – with a commitment to reach a fundraising minimum of $250
    • $85 – no commitment to fundraise
  • Virtual Cyclist Registration: FREE, and no commitment to fundraise

NOTE: Please choose the RASopathies Network Riders when you register.

Don’t bike? No problem!

You can sign up for the Million Dollar Mile and walk a mile with fellow Rare Disease advocates! Choose that option on the Penn MDBR Registration page.

More on the Penn Website and to register HERE

For more information or questions, contact us at

Ways to Donate

You can donate to RASopathiesNet for our 1:1 match up to $10,000 – which will then be sent to Penn for their 1:1 match which increases the value of your donation 4x, or you can donate through any of Penn’s webpages (RASopathies Network Riders, a friend’s or your own MDBR social fundraising page) for Penn’s 1:1 match.

Donate to RASopathiesNet for your donation-X-4.  Click here and follow option [1].  Please write “MDBR” in the memo of your donation


Donate to Penn MDBR’s RASopathies Network Riders’s donate page – click here


Set up a giving page at the MDBR site to raise funds for international RASopathies research. Please contact Cara Borian at for more information on how to set up a giving page

Questions? Contact Cara Borian at

Click here for parents’ answers to
What do you hope RASopathies research will do for you?


2022 Grant Winner
Congratulations Dr. Jaffré!

$75,431 awarded thanks to our community riders and supporters matched by Penn Orphan Disease Center (OCD)


Congratulations, Vanessa Fear, PhD, The University of Western Australia, for winning the 2021 MDBR RASopathies Research Grant to study “Understanding RASopathies to better inform diagnosis and treatment”


The 2020 Final Count…


Congratulations, Gregor ANDELFINGER, MD PhD, for winning the 2019 MDBR RASopathies Research Grant studying the use of MEK inhibitors for heart problems in RASopathies!


2019 MDBR RASopathies Riders and Volunteers



Congratulations, BRUCE GELB, MD, for winning the 2018 MDBR RASopathies Research Grant!


The 2018 Final Count…

On May 21, 2018

***Thank you 2018 Riders and Volunteers!***


Thank you Water Station Volunteers!


Thank you Ride for Shane Team!


Thank you PJ for organizing all the riders!


Between their butts and the green ribbon is the RASopathiesNet logo!

RASopathiesNet’s Boardmembers Beth Stronach (Secretary) and Lisa Schill (Vice President)


Thank You Everyone!


for RASopathies Research

Thank you 2017 RASopathies MBDR Team!



Past RASopathies Grant Winners

2021: Vanessa Fear, BSc (Hons), PhD, The University of Western Australia, Telethon Kids Institute, $69,885
Understanding RASopathies to better inform diagnosis and treatment

2020: Gregor Andelfinger, MD PhD, CHU Sainte Justine Research Center, Université de Montréal, $59,220
MEK inhibition for RASopathy associated hypertrophic cardiomyopathy

2019: Bruce Gelb, MD, Icahn School of Medicine at Mt. Sinai, NY , $74,830
Advancing A Novel Therapeutic Lead for RASopathies 

2018: Kartik Venkatachalam, PhD, McGovern Medical School, University of Texas Science Center at Houston, $47,189
Targeting Endolysosomal Proteins to Treat RASopathies 

2017: Philip Stork, MD, Oregon Health Sciences University, $44,000
Are Raf dimers targets for therapeutic intervention in RASopathies?

2016: Giuseppe Zampino, Università Cattolica Sacro Cuore, $53,000
Pain in RASopathies: new investigative techniques and treatments

2015: Maria Kontaridis, PhD, Beth Israel Deaconess Medical Center/Harvard Medical School, $65,000
Pilot study to delineate the cause of gastrointestinal abnormalities in RASopathy disorders using human inducible pluripotent stem cells (iPSCs)


Save the Date!
8th International RASopathies Symposium
July 21-23, 2023
Denver, Colorado