Restoring the brake: Using molecular glues to fix a broken CRAF off-switch in Noonan Syndrome
Another RAS Dialogue Blog post has dropped from the NCI Frederick National Lab RAS Initiative referencing RASopathies!
It highlights work from the lab of Dr. Michelle Arkin, professor of Pharmaceutical Chemistry at UCSF. Her lab develops approaches to target currently ‘undruggable’ proteins important for human disease.
Dr. Arkin’s student, Johanna Virta, contributed to this scientific project asking whether it would be possible to restore the ‘brake’ in RAS-RAF-MEK-ERK signaling that is broken in Noonan syndrome.
The target of their work is the CRAF (RAF1) protein complex with the 14-3-3 protein (See figure below).
Read their insights on how a ‘molecular glue’ might provide a new therapeutic angle for RASopathy conditions like Noonan syndrome.
